Gut & Microbiome

AhR activation decreases intestinal FXR activity

Insufficient Gut & Microbiome

RefutedContestedStrong support

consensus score 0.00

⚖️ Thin evidence — read the needle loosely. The score shows which way the studies lean, but there are too few independent, high-quality ones to place it firmly. Expect this to move as better evidence arrives.

📅 Last reviewed: 2026-08-11 ⓘ

Evidence ladder

How far up the ladder this claim has climbed. A high consensus on a low rung means "consistent so far," not "proven in people."

Top evidence so far: ()

MechanismIn-vitroAnimalObservationalRCTMeta-analysis

How the studies fall

0 support 0 contradict 0 tested null 0 mixed · 0 sources, 0 independent groups

What the evidence shows

This is the novel hinge of H1 and it is unevidenced. The whole 'sensitize-and-trigger' design rests on AhR activation antagonising FXR so that FFAR2 is upregulated.

The evidence (0)

Source	Grade	Stance	Quality	Finding

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Educational only, not medical advice. Grades and scores reflect published evidence weighted by study design and quality; see the methodology.