Supplements · Food Safety
phlorizin is safe at food-relevant doses
📅 Last reviewed: 2026-08-11 ⓘ
Evidence ladder
How far up the ladder this claim has climbed. A high consensus on a low rung means "consistent so far," not "proven in people."
Top evidence so far: Animal studies (Animal)
How the studies fall
What the evidence shows
Gate on the apple-pomace/SGLT1 formulation, and the finding is an absence rather than a result. I searched for human safety data on phlorizin at dietary doses and found none. The retrieved literature is rodent and cell work, and most of it reports putative benefits (antioxidant, cognitive, cardioprotective) rather than testing safety.
The evidence (2)
| Source | Grade | Stance | Quality | Finding |
|---|---|---|---|---|
| Yu YW, et al. 2024 · International immunopharmacology | animal | supports | low | Phlorizin 1 mg/kg/day for 28 days in rats and 120 uM in AC16 cells was protective in sepsis-induced myocardial dysfunction via autophagy. Benefit study in a disease model, not a safety assessment, and the dose is pharmacological. |
| Yamaguchi K, et al. 2011 · Drug metabolism and disposition: the biological fate of chemicals | animal | tested-null | low | PK/PD model of phlorizin's inhibition of renal glucose reabsorption in rats. Characterises potency and exposure but reports no safety or toxicity endpoint, and no human data. Included to document that the pharmacology literature does not address dietary safety. |
Disagree, or know a study we missed?
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