Longevity & Aging
Does the red-wine compound resveratrol extend lifespan?
The claim, precisely: resveratrol increases lifespan
Contested Longevity & Aging 🔬 Includes disconfirming
RefutedContestedStrong support
consensus score -0.10
No — it only helped mice on high-fat diets, failed rigorous tests, and has no human data.
Evidence ladder
How far up the ladder this claim has climbed. A high consensus on a low rung means "consistent so far," not "proven in people."
Top evidence so far: Human trials (RCT / n-of-1)
MechanismIn-vitroAnimalObservationalRCTMeta-analysis
How the studies fall
1 support 1 contradict 6 tested null 5 mixed · 13 sources, 2 independent groups
What the evidence shows
Mouse benefit only on a high-fat diet (Baur-Sinclair 2006); NO extension on normal diet (Pearson 2008) and null in the NIA Interventions Testing Program (Miller 2011). No human outcome data.
The evidence (13)
| Source | Grade | Stance | Quality | Finding |
|---|---|---|---|---|
| Bass 2007 · Mech Ageing Dev | animal | tested-null | high | No significant lifespan extension in Drosophila across 7 trials; C. elegans effects variable and SIR-2.1-independent - fails to replicate Sinclair invertebrate claim |
| Wood 2004 · Nature | animal | supports | moderate | Original STAC claim: resveratrol extended C. elegans/Drosophila lifespan, Sir2-dependent, no fecundity cost - landmark pro-claim, later poorly replicated ⚠️ correction-on-file (Crossref) - kept, corrigendum not retraction |
| Chaplin 2018 · Nutrients | mechanism | mixed | low | Reviews resveratrol-microbiota metabolic effects; notes clinical trials inconclusive - mechanism plausible, human longevity evidence lacking |
| Baur 2006 · Nature | animal | mixed | moderate | [FT-verified] Baur2006: survival gain ONLY in high-cal(obese) mice not standard diet; metabolic-rescue not true longevity |
| Sahebkar 2013 · Nutr Rev | meta-analysis | tested-null | moderate | 7-RCT meta-analysis: resveratrol had no significant effect on any human plasma lipid - no cardiometabolic surrogate benefit underpinning longevity claim |
| Zhang 2006 · Biochem J | in-vitro | mixed | moderate | Resveratrol inhibits insulin signaling SirT1-independently - mechanism may extend life via IIS pathway, but decouples effect from SIRT1 narrative |
| Miller 2011 · J Gerontol A | animal | tested-null | high | [FT-verified] Miller2011 NIA-ITP: resveratrol 300/1200ppm NO survival effect; rapamycin did. Robust null in healthy mice |
| Moussa 2017 · J Neuroinflammation | RCT | mixed | moderate | 52wk resveratrol in mild-moderate AD attenuated CSF Abeta40/ADL decline - modest disease-specific signal, not lifespan; possible immune modulation |
| Yadegar 2024 · Phytother Res | observational | mixed | low | SR older adults: resveratrol no better than placebo in diabetes/PAD; high doses raised some CV-risk biomarkers - net unsupportive of longevity benefit |
| Huang 2016 · Obes Rev | meta-analysis | tested-null | moderate | Pooled RCTs overweight/obese: no significant effect of resveratrol on most CV-risk markers/body weight - human surrogate data do not support benefit |
| Pearson 2008 · Cell Metab | animal | tested-null | high | [FT-verified] Pearson2008: resveratrol does NOT increase longevity of ad-lib mice started midlife despite healthspan gains |
| Gliemann 2013 · J Physiol | RCT | contradicts | high | Resveratrol BLUNTED exercise-induced gains in VO2max, BP and lipids in aged men - actively harmful to a healthspan endpoint, opposite of claim |
| Uggioni 2025 · Nutr Metab Cardiovasc Dis | meta-analysis | tested-null | moderate | SR/MA postmenopausal women: resveratrol did not significantly improve lipid profile - independent null on a longevity-relevant surrogate |
Educational only, not medical advice. Grades and scores reflect published evidence weighted by study design and quality; see the methodology.