Supplements

riboflavin decreases homocysteine

Insufficient Supplements 🔬 Includes disconfirming

RefutedContestedStrong support

consensus score 0.74

⚖️ Thin evidence — read the needle loosely. The score shows which way the studies lean, but there are too few independent, high-quality ones to place it firmly. Expect this to move as better evidence arrives.

📅 Last reviewed: 2026-07-15 ⓘ

Evidence ladder

How far up the ladder this claim has climbed. A high consensus on a low rung means "consistent so far," not "proven in people."

Top evidence so far: Human trials (RCT / n-of-1)

MechanismIn-vitroAnimalObservationalRCTMeta-analysis

How the studies fall

3 support 0 contradict 1 tested null 0 mixed · 4 sources, 1 independent group

What the evidence shows

Riboflavin (~1.6 mg/d) lowers homocysteine and systolic blood pressure specifically in MTHFR 677TT homozygotes (riboflavin is the MTHFR enzyme's FAD cofactor). const W={mechanism:1,"in-vitro":1,animal:2,observational:3,RCT:5,"meta-analysis":8,"n-of-1":5},Q={low:.5,moderate:1,high:1.5},S={supports:1,contradicts:-1,"tested-null":0,mixed:0}; const c=dv.current().file.link,ap=dv.pages('"vault"').

The evidence (4)

Source	Grade	Stance	Quality	Finding
Rooney M, Bottiglieri T, Wasek-Patterson B, et al. 2020 · Biochimie	RCT	supports	moderate	RCT of riboflavin in screened MTHFR TT adults (n=115 plasma samples from prior RCTs): examines one-carbon metabolites and their responsiveness to riboflavin in the TT genotype. NOTE ON INDEPENDENCE: same McNulty/Ulster group as every other source on this claim - adds evidence but NOT an independent network.
jingo-2020 2020	observational	tested-null	moderate	Riboflavin status modulates 677TT hypertension risk across adulthood.
horigan-2010 2010	RCT	supports	moderate	Riboflavin lowered systolic BP ~13 mmHg in 677TT (none in CC/CT).
wilson-2013 2013	RCT	supports	moderate	SBP -5.6 mmHg on top of antihypertensives in 677TT (P=0.033).

Disagree, or know a study we missed?

We grade by evidence, not opinions. The way to weigh in is to point us to a study we haven't cited (check the evidence table above first), or to flag a problem with one we have. Every submission is reviewed; if it holds up, the grade updates and shows in Science Changes Its Mind.

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Educational only, not medical advice. Grades and scores reflect published evidence weighted by study design and quality; see the methodology.