🧪 Supplement
Folate & L-methylfolate
Folate's proven role is neural-tube-defect prevention, where ordinary folic acid works. The marketing case for L-methylfolate rests on better bioavailability, which is real — but on the endpoint that matters clinically, homocysteine lowering, head-to-head trials find the two essentially equivalent. Bioavailability is not the same as benefit.
1 well-supported · 1 disputed. This shows how settled each sub-question is, not whether Folate & L-methylfolate is "good." Direction lives in each claim below.
The 4 claims about Folate & L-methylfolate
Each keeps its own verdict — we never average them away.
folic acid decreases cardiovascular disease
Strong support
folic acid decreases recurrent pregnancy loss
Contested
L-methylfolate decreases homocysteine
Contested
L-methylfolate treats mood disorder
Leans against
Educational only, not medical advice. Hub descriptions are curated for honesty; see the methodology.