• concept

MTHFR C677T

A common enzyme variant that reduces folate processing and modestly raises homocysteine. It attracts far more claims than the evidence carries: major guideline bodies advise AGAINST routine MTHFR testing, and the practical implication is almost always 'measure the number (homocysteine, B12, folate) and treat that', not 'treat the genotype'.

2 well-supported · 0 disputed. This shows how settled each sub-question is, not whether MTHFR C677T is "good." Direction lives in each claim below.

The 3 claims about MTHFR C677T

Each keeps its own verdict — we never average them away.

MTHFR C677T increases homocysteine

Strong support

MTHFR C677T increases PCOS

Strong support

MTHFR C677T decreases vitamin D

Contested

Educational only, not medical advice. Hub descriptions are curated for honesty; see the methodology.