Health Topics / Medications
Medications 9 topics · 69 claims
Prescription drugs and their off-label uses, from statins and metformin to the new GLP-1s.
Statins
11 claimsCholesterol-lowering drugs. Strong evidence they lower LDL and cut cardiovascular events (clearest in secondary prevention; smaller but real in primary pr…
Explore Statins →GLP-1 Drugs
10 claimsGLP-1 and GLP-1/GIP receptor agonists — semaglutide (Ozempic/Wegovy), tirzepatide (Mounjaro/Zepbound), liraglutide. Strong evidence they cause major weigh…
Explore GLP-1 Drugs →Metformin
8 claimsFirst-line type-2-diabetes drug, also used off-label for longevity. Strong evidence it prevents/delays diabetes, lowers insulin resistance, and causes mod…
Explore Metformin →Testosterone therapy (TRT)
10 claimsTestosterone therapy (TRT) for men with low testosterone (hypogonadism). The evidence splits cleanly by outcome: it reliably builds muscle and improves se…
Explore Testosterone therapy (TRT) →Ezetimibe
9 claimsAn oral cholesterol-absorption blocker, often added to a statin. Strong evidence it lowers LDL (~18%) and, added to a statin, further cuts cardiovascular…
Explore Ezetimibe →PCSK9 inhibitors
4 claimsInjectable cholesterol drugs (evolocumab, alirocumab). Strong evidence they cut LDL ~50–60% and reduce cardiovascular events, and they modestly lower lipo…
Explore PCSK9 inhibitors →Bempedoic acid
4 claimsAn oral non-statin LDL-lowering drug, useful for statin-intolerant patients. Strong evidence it lowers LDL (~20%) and reduces cardiovascular events (CLEAR…
Explore Bempedoic acid →Anabolic-androgenic steroids
4 claimsTestosterone-derived muscle-building drugs. They roughly double training-driven muscle gain, but independent evidence ties them to real harms — raised car…
Explore Anabolic-androgenic steroids →SGLT1 inhibition
3 claimsMore medications claims 8
Claims in this category that aren't sorted under one of the topics above. Nothing hidden — every medications claim is either behind a button or here.
Does TRT actually build muscle and cut fat in men with genuinely low testosterone?
Yes — in properly diagnosed hypogonadal men, RCTs consistently show TRT increases lean mass and reduces fat mass, with modest-to-real strength gains.
testosterone replacement therapy individualized target 400-700 improves lean mass strength and reduces fat mass in clinically low-T men
Is prostate cancer risk unchanged by testosterone level (the saturation model)?
The old "testosterone feeds prostate cancer" fear is not supported by modern data — androgen receptors saturate at low T, and TRT has not been shown to raise prostate-cancer risk in reassuring but non-randomized evidence.
testosterone and TRT does not cause prostate cancer
Do statins raise diabetes risk more than the small label suggests?
Partly supported and clinically important: statins clearly and reproducibly raise new-onset diabetes (about 9-12% relative, dose-dependent, higher in prediabetes), which is more than trivial for at-risk patients — but in most populations the CVD benefit still outweighs it.
statin therapy increases type 2 diabetes risk to a degree greater than the small regulatory framing suggests
Does taking insulin for type 2 diabetes make the disease worse over time?
No — the one large randomized trial (ORIGIN) found insulin cardiovascular-neutral, and long-term follow-up (UKPDS) shows a durable benefit, not harm. Observational 'insulin causes harm' signals are confounded (sicker patients get insulin). Important: this is not a reason to stop or reduce prescribed insulin — for many people, especially with type 1 diabetes, insulin is life-saving, and any change should only be made with your physician.
exogenous insulin therapy for T2D worsens long-term T2D outcomes
Can teenage anabolic-steroid use permanently stunt height?
Yes — androgens aromatize to estrogen, which prematurely fuses the growth plates; this is well-established endocrinology (high-dose testosterone is even used clinically to close plates in very tall teens), so steroid use before growth finishes can permanently limit height.
adolescent anabolic-steroid use decreases adult height via growth-plate closure
Is rapamycin proven to make animals live longer also proven to extend human lifespan?
Robustly extends lifespan/healthspan in mice across independent labs, but in humans only short-term safety and immune-biomarker data exist — no human longevity outcome, exactly as Attia's hedged framing states.
rapamycin increases healthspan and lifespan
Can blocking an enzyme (IDO1) that both amyloid and tau switch on rescue memory in Alzheimer's models?
One strong mouse/cell study (Science 2024) shows amyloid and tau activate astrocytic IDO1->kynurenine, choking brain glucose use, and that blocking IDO1 restores memory; independent data confirm kynurenine pathway disturbance in human AD but the memory-rescue causal claim rests on this single lab.
IDO1 inhibition (blocking tryptophan->kynurenine) improves memory
Can food boost the effect of GLP-1 weight-loss drugs?
Unknown, because no trial has tested it. Food does not reliably raise this hormone even on its own, and there are reasons to expect it would add nothing on top of the drug, but that has not been shown.
dietary endogenous-GLP-1 stimulation increases exogenous GLP-1 RA drug effect